This award is named for the late AJNR Senior Editor who championed its establishment and recognizes the best original research paper accepted in 2016. The winning paper, submitted by authors from the Texas Children’s Hospital in Houston, was published electronically on October 13, 2016 and appeared in the February print issue. It was selected by a vote of the Journal’s Editor-in-Chief and Senior Editors.
A cohort of 44 preterm infants underwent T1WI, resting-state fMRI, and DTI at 3T, including 21 infants with brain injuries and 23 infants with normal-appearing structural imaging as controls. Neurodevelopment was evaluated with the Bayley Scales of Infant Development at 12 months’ adjusted age. Results showed decreased fractional anisotropy and elevated radial diffusivity values of the cingula in the preterm infants with brain injuries compared with controls. The Bayley Scales of Infant Development cognitive scores were significantly associated with cingulate fractional anisotropy. The authors suggest that the microstructural properties of interconnecting axonal pathways within the default mode network are of critical importance in the early neurocognitive development of infants.
Dr. Susan Mackinnon is a world-renowned expert in all aspects of peripheral nerve injury and repair, from basic science to surgery and clinical treatment to clinical discovery. She has served as Professor and Chair of Plastic Surgery at Washington University School of Medicine for almost two decades.
As an author of more than 500 articles in numerous areas of nerve injury and repair, she is likely best known for her work on the development of nerve allograft repair with immunosuppression, the understanding of tubular nerve repair strategies, and more recently, nerve transfers. She co-authored a book with Lee Dellon in the late 80s on peripheral nerve surgery, and the current textbook, now almost 30 years later, is a much-needed update on and advance in the field.
The book is organized into sections, going from basic science and anatomy and physiology of nerve repair to the concept of nerve grafting. As opposed to the previous text, there is a real focus on nerve transfers, a relatively new area of peripheral nerve surgery. The text is extremely well-organized and of enormous value as a reference text for any practitioner involved in nerve repair.
The neuroradiology aspects of this book are relatively minor and limited—mostly to images of tumors of the peripheral nervous system. The area of imaging of nerve injuries is really a sub-subspecialty within this field of neuroradiology and is essentially not covered in this text.
The text does cover many of the surgical aspects of peripheral nerve repair, including (but not limited to) direct nerve repair, nerve graft, and nerve transfers. It includes entrapment neuropathies as well as tendon transfers for functional recovery.
The images are excellent and clearly labeled. Only a few are taken from the original …
Don’t miss this course in neuroradiology and neurosurgery!
Mark your calendars for March 24-25, 2017.
Program topics include:
Y-stenting for aneurysm treatment
The seminar is accredited for 14.75 AMA PRA Category 1 Credits™ by the ACCME through the joint providership of the Mayo Clinic College of Medicine and is compliant with theEucomed Code of Ethical Business Practice.
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Led by Jacques Moret and faculty, we are gearing up for the seminar with recorded cases focusing on a wide variety of themes and techniques linked to our specialty. Our program is being adapted in real time to fit your needs and provide you with tips and tricks that are directly applicable to your daily practice.
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During most MRI procedures, there is no need for interaction between the administrator of the test and the patient. The situation is quite the opposite in functional MRI (fMRI), where the neurological status of the patient must be assessed; an appropriate paradigm must be selected based on the neurological assessment and prior MRI examinations. Further, the paradigm must be delivered to and successfully performed by the patient while in the MRI machine. In addition, there is a rather complicated analysis of the fMRI and diffusion tractography data, which must be performed and assessed. How to properly perform these tasks is often not addressed during residency and fellowship training or in annual scientific society meetings.
Clinicians involved in fMRI, including neuroradiologists, neurosurgeons and neurologists.
Understand the fundamental principles behind fMRI and diffusion tractography
Choose the optimal fMRI paradigms appropriate for the patient and clinical situation
Deliver fMRI paradigms correctly and monitor the patient for adequate compliance
Hands on experience so that the attendee will be able to analyze fMRI and diffusion tractography
Understand how data is delivered to a neurosurgical navigational system and used by the neurosurgeon
Avoid pitfalls in the interpretation of clinical fMRI and diffusion tractography
Optimize fMRI billing and coding
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the International Institute for Continuing Medical Education, Inc. and fMRI Consultants LLC. The International Institute for Continuing Medical Education Inc. is accredited by the ACCME …
In this retrospective study, synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced in 12 patients with MS after quantification of T1 and T2 values and proton density. Double inversion recovery images were optimized for each patient by adjusting the TI. The number of visible plaques was determined by a radiologist for a set of these 4 types of synthetic MR images and a set of conventional T1-weighted inversion recovery, T2-weighted, and FLAIR images. Conventional 3D double inversion recovery and other available images were used as the criterion standard. Synthetic MR imaging enabled detection of more MS plaques than conventional MR imaging in a comparable acquisition time (approximately 7 minutes). The contrast for MS plaques on synthetic double inversion recovery images was better than on conventional double inversion recovery images.
BACKGROUND AND PURPOSE
Synthetic MR imaging enables the creation of various contrast-weighted images including double inversion recovery and phase-sensitive inversion recovery from a single MR imaging quantification scan. Here, we assessed whether synthetic MR imaging is suitable for detecting MS plaques.
MATERIALS AND METHODS
Quantitative and conventional MR imaging data on 12 patients with MS were retrospectively analyzed. Synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced after quantification of T1 and T2 values and proton density. Double inversion recovery images were optimized for each patient by adjusting the TI. The number of visible plaques was determined by a radiologist for a set of these 4 types of synthetic MR
The purpose of this study was to use DCE MR imaging to quantify the contrast permeability of intracranial atherosclerotic disease plaques in 10 symptomatic patients and to compare these parameters against existing markers of plaque volatility using black-blood MR imaging pulse sequences. Ktrans and fractional plasma volume (Vp) measurements were higher in plaques versus healthy white matter and similar or less than values in the choroid plexus. Only Ktrans correlated significantly with time from symptom onset. Dynamic contrast-enhanced MR imaging parameters were not found to correlate significantly with intraplaque enhancement or hyperintensity. The authors suggest that Ktrans may be an independent imaging biomarker of acute and symptom-associated pathologic changes in intracranial atherosclerotic disease plaques.
Brandão LA, ed. Mukherji SK, consulting ed. Neuroimaging Clinics of North America: Adult Brain Tumors. Elsevier; 2016;26(4):493–694; $360.00
This November 2016 issue of the Neuroimaging Clinics of North America consists of 9 chapters (nearly 200 pages in length) and covers a number of aspects of adult brain tumors. Edited by Dr. Lara Brandão with contributions from 21 international and national authors, this volume deals with (in order): posterior fossa tumors, lymphomas (2 chapters), the pre- and posttreatment evaluation of gliomas (2 chapters), metastasis, extra parenchymal tumors, advanced MR techniques, and interesting cases of pseudotumors. It is a bit surprising that there is not a chapter dedicated to the emerging brain tumor classifications based on molecular/genetic factors. While in our daily readings of brain MRs and CTs, we do not consider these molecular factors, these issues are discussed among members of neuro-oncology tumor boards, on which neuroradiologists are participants. With the increased emphasis on ICD types and their implications for therapy, some space on this subject is warranted. Had this been included, some of the terminology used elsewhere in the book might have been altered. Of course, the chapter on posttreatment of gliomas and the complexities in the analysis of such patients will be of great interest to the readers of this volume. The extensive material on lymphomas is important and noteworthy because of the increased incidence of disease and the multiple parameters that can be utilized in its detection and evaluation. Many important teaching points are raised in this 54-page (2-chapter) evaluation of lymphomas.
The images included in this volume are of high quality and are well-described, with important structural changes in brain tumors included. Even if one does not read the volume cover-to-cover, one can derive an understanding (providing a good review) of adult brain tumors and see …
Dr. Schaefer is a recognised clinical expert in neuroradiology especially in acute stroke imaging. She has held leadership positions in multiple regional and national societies, including President of the American Society of Neuroradiology, Eastern Neuroradiology Society and the New England Roentgen Ray Society. She is also a renowned educator, teacher and editor; and a respected administrator at Massachusetts General Hospital in Neuroradiology and Clinical MRI.
Dr Bertrand Ang is a senior consultant working in National University Hospital Department of Diagnostic Imaging. He specialises in body radiology with a special interest in oncology. He graduated from University of New South Wales (Australia) in 1998 and finished his radiology speciality with Master of Medicine (Radiology) National University of Singapore and Fellowship Royal College of Radiology in 2005. He is active in various tumour groups including Colorectal, Gynaecological and Urological tumour groups.
Richard H Wiggins
Dr. Richard H Wiggins is the Director of Head and Neck Imaging and the Director of Imaging Informatics at the University of Utah Health Sciences Center. He has served as the President of WNRS and ASHNR, and Program Chair for SIIM. He was elected the inaugural fellow of the Academy of Medical Science Educators, and is the recipient of the Teacher of the Year award from the Department of Radiology, the Distinguished Teaching Award from the Department of Otolaryngology, as well as the Honoured Educator Award from the Radiological Society of North America.
The 2017 RadiologyAsia Conference, themed “Bringing the State of the Art Imaging to Clinical Practice”, brings incredible value to attending delegates. The conference will feature 74 topics, over 50 renowned speakers and 4 tracks. Sign up today to learn and gain new insights from Pamela Schaefer, Bertrand Ang, Stephen Bird, Regina J Hooley, James G Smirniotopoulos, Ashish Chawla, Howard …
Domino JS, Baek J, Meurer WJ, et al. Emerging temporal trends in tissue plasminogen activator use. Neurology. 2016;87(21):2184-2191. doi:10.1212/WNL.0000000000003349.
Mexican Americans (MA) have an increased stroke burden when compared to their non-Hispanic white (NHW) counterparts, including increased stroke incidence and poorer neurologic, functional, and cognitive outcomes.
The authors explored the temporal trends in tissue plasminogen activator (tPA) administration for acute ischemic stroke (AIS) in a biethnic community without an academic medical center. Cases of AIS were identified from 7 hospitals in the Brain Attack Surveillance in Corpus Christi (BASIC) project, a population-based surveillance study from 2000-2012. There were 5,277 AIS cases identified from 4,589 individuals. tPA use was steady at 2% and began increasing in 2006, reaching 11% in subsequent years. Although ethnicity did not modify the temporal trend, Mexican Americans were less likely to receive tPA than non- Hispanic whites due to emerging ethnic differences in later years. The results suggest that increases in tPA use were greater in higher severity patients compared to lower severity patients, and a gap between MAs and NHWs in tPA administration may be emerging. The authors conclude that as physician experience with tPA and its use in community settings increases, follow-up studies should continue to explore temporal trends in tPA as well as identify possible strategies to improve tPA use in MAs.
2 Figures (graphs), 2 Tables
Goldstein LB. IV tPA for acute ischemic stroke. Neurology. 2016;87(21):2178-2179. doi:10.1212/WNL.0000000000003366.
In this editorial on the Domino et al. paper, Dr. Goldstein notes that there were considerable barriers that slowed IV tPA adoption after it was approved by the FDA in 1996. Eight years after FDA approval, IV tPA was being given to only 1%–2% of stroke patients. Transformation of the structure and organization of stroke care delivery were needed, and in part led …