Monthly Archives: February 2009

Using DTI-MRI in Geron’s Phase I Clinical Trial

What do you think about the use of DTI-MRI for tracking the progress of therapy in Geron’s upcoming Phase I clinical trial? DTI measures (transverse and longitudinal diffusivity) in some rodent models of spinal cord injury have shown correlations with myelination and axonal integrity. If the intraspinally injected oligodendrocyte progenitor cells are indeed remyelinating damaged axons, then perhaps tracking patients with non-invasive DTI-MRI could allow the investigators to better assess the outcomes of their intervention?… Continue reading >>

Posted in Spine | Tagged , , | Leave a comment

Blogging Terminology

For many of us, using ajnrblog.org is probably our first blogging experience.  Here are some terms from the blogosphere that you may find useful:

1.  Blogsite: a collection of posts.

2. Posts: a single unit of content; generally a title and a short text with or without audiovisual enhancements.

3.  Thread: a specific post  followed by a series of commentaries.

4.  Tag: a language element descriptor(s) used to identify types of content(s) making up posts.

5.  Byline: the name of the author (and other information regarding him/she) of a post or comment.

6.  Tag cloud: visual representation of tags or … Continue reading >>

Posted in Editorial Issues | Tagged | Leave a comment

We Published a Case (Cord Herniation) Some Years Ago. In the Attachment You Will Find Some Images in a PPT File.

Spinal Cord Herniation (.ppt)Continue reading >>

Posted in Spine | Leave a comment

fMRI Visual Paradigms

I am upgrading the fMRI lab at our institution. Which system do you suggest to present visual paradigms, mirror over the head coil and video beam wall projection Vs binocular glasses… Continue reading >>

Posted in Brain, Functional | Tagged , | Leave a comment

Celiac Disease with Brain ALS-like Abnormalities

We just had a patient with ALS-like brain changes on FLAIR images who has celiac disease.  After a 3-month period of  treatment for his celiac disease, brain MRI was repeated and all previously seen abnormalities resolved.  We are interested in reporting it and would like to collaborate with anyone who has a similar case.  Please post a comment here or email me.… Continue reading >>

Posted in Brain | Tagged , , | Leave a comment

Validation and Standardization of Stroke Perfusion Methods

CTP and MRP acquisition hardware, protocols,  post processing, and interpretation vary widely between centers.  If we are to use these techniques for rational triage of acute stroke patients to appropriate treatment, validation and standardization is required.  I encourage all who perform such imaging to participate in the “STIR” effort, being corrdinated by Max Wintermark et al at UCSF.… Continue reading >>

Posted in Brain | Tagged , , , , , | 1 Comment

Fetal MRI

fig3b_narrows_6-17-copyI was wondering how many sites are doing fetal MRI, and who is interpreting the images (neuroradiologists, pedi neuroradiologists, other radiologists, perinatologists, pedi neurosurgeons). If you do fetal MRI at your site (academics or private practice), it would be great to hear from you. Thanks.… Continue reading >>

Posted in Pediatrics | Tagged | 3 Comments

Posterior Fossa Vascular Anomaly

I recently saw a patient with a solitary artery arising from the PCA on on each side coursing downwards to supply the cerebellum and the vermis on the same side. Has there been any similiar observations/publications?… Continue reading >>

Posted in Interventional | Leave a comment

Asymmetric Disks

We often see asymmetric disks, bulge or protrusion, where the side of radiculopathy is opposite the side of maximum disk protrusion in the spinal canal. Have others noticed this as well?… Continue reading >>

Posted in Spine | Tagged | 3 Comments

Vascular Calcifications

I would really appreciate your opinions on the following. We see calcified carotid atheromas (CCA) in the neck on a regular basis as incidental findings in (maxillofacial) cone-beam CT scans of our patients. Sometimes we also see intracranial calcification in the wall of the internal carotid artery (in the carotid sulcus), usually in addition to calcifications in the neck. Considering the potential increased risk for stroke, we recommend that patients with CCA in the neck are referred to the physician for further testing (ultrasound). Occasionally, we only see intracranial calcification in the ICA without calcifications in the neck. What should be … Continue reading >>

Posted in Head and Neck | 1 Comment