Monthly Archives: March 2009

Search for CNS’s Drug-Induced Changes

I’m very interested in different cases of CNS changes induced by any kind of recreational drug. Please, If you are also interested, contact me.… Continue reading >>

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Willinsky RA et al, Clinical and Endovascular Follow-Up of Embolized Aneurysms

A recent article published by Dr Robert Willinsky and colleagues from Toronto is noteworthy and an excellent addition to the literature on the subject of endovascular treatment of ruptured aneurysms. This is one of the largest series on this subject and addresses, amongst other things, the important issue of rebleeding after endovascular repair.

In this large series, the rehemorrhage rate after embolization was 2.1%. The risk of rebleeding was 1.6% in the first 30 days, decreasing to 0.7% after this time. The authors use a protocol of imaging the ruptured aneurysms with enhanced MRA at the time of discharge, followed … Continue reading >>

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Liver Hemangiomas and Vascular Lesions of the Brain

I have a patient with 15 large liver hemangiomas and two partly calcified lesions in brain.

Does anyone know of  associated liver hemangiomas and vascular lesions in the brain?… Continue reading >>

Posted in Brain | Tagged | 2 Comments

ADC Question

I will like to know if someone can help me with some doubts I have regarding ADCs.

1.  I have  a sample with some ADC values obtained in 1,5 T and others obtained in 3T ( same b value). Can I use the ADC values for statistics or do you think that they cannot be compared?

2.  Are the ADC values obtained using a diffusion sequence  the same that the ADC values obtained in a DTI sequence with 12 directions?

Thank you in advance.… Continue reading >>

Posted in Brain, Functional | Tagged , , | 1 Comment

MIT Goes Open Access

In one of my previous editorials I commented on Harvard’s open access (OA) initiative (AJNR 2008; 29: 617-18). Basically, regardless of publication venue, all investigators working for that institution have to deposit a copy of their articles in a free and unrestricted site. This means that Harvard researchers, even if they have signed AJNR’s copyright agreement make their works OA through that site. For many years, this formula has been required for employees of the Military and government agencies. We at AJNR understand these policies and have adapted our copyright for those requesting it and even release ownership of articles … Continue reading >>

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Midbrain Hamartoma

We have an interesting case of a 30 year old female who had an MRI study for right sensory neural hearing loss. Incidentally found on her scan was a 1.2 cm lesion in the region of the left subthalamic nucleus extending to the cerebral peduncle with mild expansion which appears isointense to gray matter on all sequences with no evidence of enhancement. Single voxel spectroscopy showed elevation of myoinositol. No decreased NAA and no increased choline. A one year follow up MRI showed no changes in size of the lesion. This lesion is felt to represent a hamartoma; however, most … Continue reading >>

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Intracranial Hypotension: Advice on Best Treatment

Middle age female patient diagnosed with Spontaneous intracranial hypotension.  Has multiple (approx 23) perineural cysts.  Has undergone several blood patches and artificial CSF infusions without relief.  Does anyone have any thoughts on other therapies, new techniques, experts in field.  Appreciate the input.… Continue reading >>

Posted in Interventional, Spine | Tagged , | 10 Comments

Editor’s and Fellows’ Journal Club Choices, March 2009

Editor’s Choices

Proton MR Spectroscopy Improves Discrimination between Tumor and Pseudotumoral Lesion in Solid Brain Masses • C. Majós, C. Aguilera, J. Alonso, M. Julià-Sapé, S. Castañer, J.J. Sánchez, Á. Samitier, A. León, Á. Rovira, and C. Arús

Differentiating between true neoplasms and lesions that look like neoplasms is difficult with conventional imaging methods. In this study, the authors investigated the clinical utility of MR spectroscopy in this setting. They examined 68 glial brain tumors and 16 pseudotumoral lesions (mostly demyelinating and infarctions). On short echo-time MR spectroscopy, pseudotumors showed higher myo-inositol than tumors, and on long echo-time MRS, tumors … Continue reading >>

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Another One Bites the Dust: JCI Says Goodbye to Open Access

One of my previous editorials (AJNR 2008; 29: 1805) dealt with the issue of open access (OA) and its influence on medical journals. Although complete OA is laudable, it is a difficult economic model to sustain. The BMJ was one of the major first OA journals and also one of the first to return to a subscriber fee model. In 1996, the Journal of Clinical Investigation became OA and starting this year it returned to a subscriber model (http://scholarlykitchen.sspnet.org/2009/02/26/end-of-free-access/). Both, BMJ and JCI are prestigious, widely cited journals initially perceived as ideal models for OA. Moreover, JCI charges authors for … Continue reading >>

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Thyroid Nodules and Diffusion

This month (Feb. 2009), there is an article in AJNR regarding differentiating cold thryoid nodules as benign vs. malignat on DWI.  link:  http://www.ajnr.org/cgi/content/full/30/2/417.  A similar article by Bozgeyik et al (abstract below) appeared in the March 2009 issue of ‘Neuroradiology’ (see below).  The current article in AJNR reports that malignant thyroid nodules demonstrated increased ADC values compared with benign ones, whereas the article in Neuroradiology reports lower ADC maps for malignancy.  Similarly the article by Razek et al in March, 2008 AJNR (link:  http://www.ajnr.org/cgi/content/full/29/3/563) reported lower ADCs for malignant nodules.

Does anyone have any thoughts on possible reasons … Continue reading >>

Posted in Head and Neck | Tagged | 2 Comments