Monthly Archives: June 2009

Principles of Bone Biology, 3rd ed.

Principles of Bone Biology, 3rd ed.  J.P. Bilezikan, L.G. Raisz, and T.J. Martin, eds. Elsevier; 2008, 1900 pages, $429.00.

Principles of Bone Biology is an excellent single-source review of the rapidly expanding knowledge base of the biology of bone. Nearly 200 authors contributed to the 90 chapters in this book. The text is authoritative, comprehensive, scholarly, and up-to-date. The editors present us with a well-constructed and well-written narrative. The first part of the book guides the reader from the very basics of cell biology, through the biochemistry, endocrinology, and homeostatic mechanisms of bone. The succeeding parts of the book focus … Continue reading >>

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Osteoporosis: Two-Volume Set, 3rd ed.

Osteoporosis: Two-Volume Set, 3rd ed.
R. Marcus, D. Feldman, D.A Nelson, and C.J. Rosen, eds. Elsevier; 2007, 2016 pages, $420.00.

Osteoporosis affects a large percentage of the elderly population. Fractures incurred by these patients have significant consequences both in human and economic terms. The disease, however, is by no means restricted to this segment of the population. Osteoporosis, a third-edition 2-volume textbook edited by Marcus et al delves deeply into the subject.

With contributions from more than 150 authors and a total of 80 chapters, the book gives a thorough overview of the subject of osteoporosis. It is organized … Continue reading >>

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Other Journals

I like features in the journals that keep you up to date with other literature, like the old annotated bibliography that AJNR used to have.  In that spirit, I will throw out some current literature that you might not have run across:

Occurrence of Basal ganglia germ cell tumors without a mass.  Arch Neurol  2009; 66(6): 789-792.  Kinda scary.  BG germ cell tumors, biopsy proven, presenting with volume loss and even wallerian degeneration.  Also hypometabolism on PET.

The timing and influence of MRI on the management of patients with cervical facet dislocations remains highly variable.  J Spinal Disord Tech 2009; … Continue reading >>

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Trigeminal Cystic Schwannomas

We present two cases of cystic lesions in the Meckel’s cave, both of which showed fluid-fluid levels on MR images and are consistent with trigeminal cystic schwannomas.

Fluid-fluid levels are the result of mucinous areas or microcysts, or as a result of necrosis and hemorrhage. The fluid is unclotted blood against serous fluid. In addition, in areas of necrosis, the fluid that fills a necrotic cavity early on tends to be more proteinaceous than newer interstitial fluid. In such cases, fluid separation, based on viscosity and protein content, may occur. When fluid levels are seen in masses arising from nerves, schwannoma … Continue reading >>

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AJNR’s New Impact Factor: 2.745, A Record High!

Today, the ISI Web of Knowledge released the new Journal Citation Reports which include metrics that analyze the performance of biomedical journals. AJNR’s impact factor went up from 2.338 (last year) to 2.745 with a 5-year I.F. of 3.010. These are the highest impact factors our journal has had. They are a reflection of the high quality of our original articles, great review articles and a decreased number of case reports.… Continue reading >>

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Mass in Septum Pellucidum

imag191 imag19a1 imag202 imag20a1

Does anyone know what this mass could be? It was biopsied 2 years ago and pathology reported it as  “normal brain tissue”.

As you can see, the lesion is hyperintense on T2, hypointense on T1 and does not enhance.  No calcifications are present and no there is no restricted diffusion .

The patient is 25  year old and has loss of short term memory and seizures.

Any input into the nature of the mass is welcome.… Continue reading >>

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Editor’s and Fellows’ Journal Club Choices, June/July 2008

Editor’s Choices

Apparent Diffusion Coefficient Values of Middle Ear Cholesteatoma Differ from Abscess and Cholesteatoma Admixed Infection • S. Thiriat, S. Riehm,S. Kremer, E. Martin, and F. Veillon
Lately, we have seen several articles and comments in AJNR and on the AJNR Blog about the use of diffusion-weighted imaging for middle ear cholesteatoma. In this retrospective study, the authors further refined the use of the technique in this clinical situation. They analyzed the images of 15 patients with suspected acquired middle ear cholesteatomas and found they could be divided into 3 groups according to their apparent diffusion coefficient ranges. These … Continue reading >>

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Anti-NMDA Encephalitis

7-yo African-American male with seizures. No fever.

Initial CT scan and labs: normal.

EEG: diffuse slowing over the left cerebral hemisphere.

Brain Biopsy (left temporal lobe): Focal necrosis, dystrophic calcification, chronic inflammation, and microglial activation (the latter suggested an infectious etiology, such as a virus, but no infectious agent was identified).

Two weeks after initial work-up he was found to have +NMDA receptor antibodies.

As part of the search for the etiology of these NMDA receptor antibodies, a testicular ultrasound, Beta-HC, AFP, PET were performed to r/o malignancy — all of these studies were negative. CT of chest, abdomen, and … Continue reading >>

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Editor’s and Fellows’ Journal Club Choices, May 2008

Editor’s Choices

The Leptomeningeal “Ivy Sign” on Fluid-Attenuated Inversion Recovery MR Imaging in Moyamoya Disease: A Sign of Decreased Cerebral Vascular Reserve? • N. Mori, S. Mugikura, S. Higano, T. Kaneta, M. Fujimura, A. Umetsu, T. Murata, and S. Takahashi
The “ivy” sign refers to increased pial and sulcal signal intensity in patients with Moyamoya disease. We know this sign is due to collateral circulation and these authors investigated the utility of the finding by reassessing it in MR studies in 48 patients with this disease. They divided the brains into 4 different regions and correlated the presence of the … Continue reading >>

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New Onset Seizure Work-Up

We recently had a debate during one of our weekly Neuro meetings on the “standard of care” for work-up of a patient with new onset seizures. As a neuroradiologist I insisted that all patients with such a history undergo an MR of the brain, and that if a CT head is done through the ER, and it is negative, the conclusion in the report should read something like “an MR of the brain should be considered for further work up of seizures.” The non-neuroradiologists in the group argued that the burden of getting an MR or not should fall upon the ordering … Continue reading >>

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