Author: bweinber

Brent Weinberg • Emory University

After training as a resident at the University of Texas-Southwestern Medical Center (UTSW) and neuroradiology fellow at the University of California-San Francisco (UCSF), I've recently started a position as an assistant professor in neuroradiology at Emory University in Atlanta, GA.

Fellows’ Journal Club Recap: Quantitative MRI for automated CSF measurements in hydrocephalus evaluation

Please check out the accompanying podcast of this blog post (discussion of this article begins at 15:07)

Current evaluation of idiopathic normal pressure hydrocephalus (NPH) depends predominantly on clinical examination, although there are some imaging features, including enlarged lateral ventricles, bowing of the corpus callosum, and enlargement of the sylvian fissures out of proportion to the other cerebrospinal fluid (CSF) spaces. However, these imaging features are largely subjective, depending heavily on the opinion of the interpreting physician.

In this paper, the authors sought to improve evaluation of idiopathic normal pressure hydrocephalus by developing an automated method for calculating CSF volumes within the calvarium, including volume in the lateral ventricles, total intracranial CSF volume, and brain parenchymal fraction. They compared this to manual segmentation and measured volumes in patients being evaluated for NPH both before and after a large volume lumbar puncture.

The results demonstrate that the method was useful for measuring CSF volumes, with good correlation between the automatic method and manual segmentation. Furthermore, the ventricular volume decreased after the large volume lumbar puncture, with the difference most pronounced 30 minutes after the procedure and gradually returning towards baseline over a 24 hour period. The method was also useful for calculating brain parenchymal fraction, which cannot be easily calculated manually.

These findings are interesting for several reasons. First, it is valuable to know that the automated method is reliable when compared to manual measurements and can be used to see how much change there is in the CSF volumes of patients being evaluated for normal pressure hydrocephalus. It is a natural extension of this study to see what the clinical outcomes were for these patients, and potentially know if there was a difference in patient that were ultimately diagnosed with NPH. Ideally, these values could potentially predict which …