Author Archives: Marcela Posada

Anomalies After Exposure to Methotrexate in the 1st Trimester

This is a 2 day-old term baby with history of methotrexate exposure during first trimester as an abortion attempt. No other relevant clinical history. [...] Continue reading

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Trigeminal Cystic Schwannomas

We present two cases of cystic lesions in the Meckel’s cave, both of which showed fluid-fluid levels on MR images and are consistent with trigeminal cystic schwannomas.

Fluid-fluid levels are the result of mucinous areas or microcysts, or as a result of necrosis and hemorrhage. The fluid is unclotted blood against serous fluid. In addition, in areas of necrosis, the fluid that fills a necrotic cavity early on tends to be more proteinaceous than newer interstitial fluid. In such cases, fluid separation, based on viscosity and protein content, may occur. When fluid levels are seen in masses arising from nerves, schwannoma … Continue reading >>

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Anti-NMDA Encephalitis

7-yo African-American male with seizures. No fever.

Initial CT scan and labs: normal.

EEG: diffuse slowing over the left cerebral hemisphere.

Brain Biopsy (left temporal lobe): Focal necrosis, dystrophic calcification, chronic inflammation, and microglial activation (the latter suggested an infectious etiology, such as a virus, but no infectious agent was identified).

Two weeks after initial work-up he was found to have +NMDA receptor antibodies.

As part of the search for the etiology of these NMDA receptor antibodies, a testicular ultrasound, Beta-HC, AFP, PET were performed to r/o malignancy — all of these studies were negative. CT of chest, abdomen, and … Continue reading >>

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