Author Archives: Mauricio Castillo

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Diagnostic Accuracy of PET for Recurrent Glioma Diagnosis: A Meta-Analysis • T. Nihashi, I.J. Dahabreh, and T. Terasawa
These authors compared the diagnostic accuracy of PET with that of CT and MRI in the diagnosis of recurrent glioma in 26 previously published articles. PET studies with either FDG or carbon methionine were obtained once glioma recurrence was suspected on CT and/or MRI. Diagnostic accuracies were heterogeneous and studies did not compare PET with other imaging modalities. Despite these limitations, PET with both tracers appears to have a moderately good accuracy as an add-on test for diagnosing recurrent glioma.… Continue reading >>

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Anatomic MR Imaging and Functional Diffusion Tensor Imaging of Peripheral Nerve Tumors and Tumorlike Conditions • A. Chhabra, R.S. Thakkar, G. Andreisek, M. Chalian, A.J. Belzberg, J. Blakeley, A. Hoke, G.K. Thawait, J. Eng, and J.A. Carrino
In this study 29 patients underwent anatomic and functional imaging (DWI and DTI) of peripheral nerve masses in an attempt to improve their characterization. ADC values were lower in malignant tumors, the involved nerves had lower fractional anisotropy, and DTI showed differences between benign and malignant tumors. The authors concluded that tractography and fractional anisotropy provide insight into neural integrity while … Continue reading >>

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Apolipoprotein E ε4 Does Not Modulate Amyloid-β–Associated Neurodegeneration in Preclinical Alzheimer Disease • R.S. Desikan, L.K. McEvoy, D. Holland, W.K. Thompson, J.B. Brewer, P.S. Aisen, O.A. Andreassen, B.T. Hyman, R.A. Sperling, A.M. Dale, and for the Alzheimer’s Disease Neuroimaging Initiative
These authors investigated the relationship between amyloid-β, phosphorylated tau, and apolipoprotein E in preclinical Alzheimer disease in 170 patients and controls who had serial imaging up to 3.5 years after the initial study. Global volumes as well as volumes in brain regions known to be involved in the chronic stages of the disease were assessed. Their results … Continue reading >>

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Pipeline Embolization Device in Aneurysmal Subarachnoid Hemorrhage • J.P. Cruz, C. O’Kelly, M. Kelly, J.H. Wong, W. Alshaya, A. Martin, J. Spears, and T.R. Marotta
The authors used the Pipeline device to treat 20 patients with acutely ruptured intracranial aneurysms. The most common types of aneurysms treated were blister and dysplastic/dissecting. Procedure-related morbidity/mortality overall was 15%, and 1 death directly related to the procedure occurred. Occlusion rates were 75% and 94% at 6 months and 12 months, respectively. The authors concluded that the Pipeline device offers a feasible treatment option in acute or subacute ruptured aneurysms, especially … Continue reading >>