Resting-state fMRI data from 36 patients with hot-water epilepsy (18 with infrequent seizures) and 18 healthy age- and sex-matched controls were analyzed for seed-to-voxel connectivity. Patients in the frequent-seizure group had increased connectivity within the medial temporal structures and widespread areas of poor connectivity, including the default mode network. Seizure frequency can alter functional brain connectivity, which can be visualized by resting-state fMRI.
BACKGROUND AND PURPOSE
The frequency of seizures is an important factor that can alter functional brain connectivity. Analysis of this factor in patients with epilepsy is complex because of disease- and medication-induced confounders. Because patients with hot-water epilepsy generally are not on long-term drug therapy, we used seed-based connectivity analysis in these patients to assess connectivity changes associated with seizure frequency without confounding from antiepileptic drugs.
MATERIALS AND METHODS
Resting-state fMRI data from 36 patients with hot-water epilepsy (18 with frequent seizures [>2 per month] and 18 with infrequent seizures [≤2 per month]) and 18 healthy age- and sex-matched controls were analyzed for seed-to-voxel connectivity by using 106 seeds. Voxel wise paired t-test analysis (P < .005, corrected for false-discovery rate) was used to identify…