May 2019 (9 papers)
1. Ebeling PR, Akesson K, Bauer DC, et al. The Efficacy and Safety of Vertebral Augmentation: A Second ASBMR Task Force Report. J Bone Miner Res. 2019;34(1):3-21. doi:10.1002/jbmr.3653.
Two placebo-controlled trials of percutaneous vertebroplasty published in 2009 questioned the value of this procedure, and an additional three trials, all in participants with acute symptoms (for up to 9 weeks), have now confirmed the findings of these earlier trials. No placebo-controlled trials of balloon kyphoplasty have been performed and evidence of the value of this procedure is reliant on low quality evidence from trials that have compared kyphoplasty with usual care or head-to-head comparisons with vertebroplasty. In addition, there have been few trials of other nonpharmacological approaches to reduce pain in patients with vertebral fractures.
The American Society for Bone and Mineral Research (ASBMR) leadership charged this Task Force to address key questions on the efficacy and safety of vertebral augmentation and other nonpharmacological approaches for the treatment of pain after VF. This report details the findings and recommendations of this Task Force.
For patients with acutely painful VF, percutaneous vertebroplasty provides no demonstrable clinically significant benefit over placebo. Results did not differ according to duration of pain. There is also insufficient evidence to support kyphoplasty over nonsurgical management, percutaneous vertebroplasty, vertebral body stenting, or KIVA®. There is limited evidence to determine the risk of incident VF or serious adverse effects (AE) related to either percutaneous vertebroplasty or kyphoplasty. No recommendation can be made about harms, but they cannot be excluded.
For patients with painful VF, it is unclear whether spinal bracing improves physical function, disability, or quality of life. Exercise may improve mobility and may reduce pain and fear of falling but does not reduce falls or fractures in individuals with VF. General and intervention-specific research …