Editor’s Choice Neurite orientation dispersion and density imaging (NODDI) assesses microstructural features of neurites contributing to diffusion imaging signals. Twenty-one subjects with MS underwent serial enhanced MRIs including NODDI, the key metrics of which are the neurite density and orientation
Editor’s Choice Mangafodipir is a manganese chelate that was clinically approved for MR imaging of liver lesions. The authors present a case series of 6 adults with multiple sclerosis who were scanned at baseline with gadolinium, then injected with mangafodipir,
Editor’s Choice Anatomic images covering the cervical spinal cord from the C1 to C6 levels and DTI, magnetization transfer/inhomogeneous magnetization transfer images at the C2/C5 levels were acquired in 19 patients with MS and 19 paired healthy controls. Anatomic images
Editor’s Choice The authors investigated the impact of intracortical lesions on the volumes of subcortical structures (especially the thalamus) compared with other lesions in 71 patients with MS. The volumes of intracortical lesions and white matter lesions were identified on
Editor’s Choice In this review, the authors provide an appraisal of the current literature on the physics principles, histopathologic validation, and clinical applications of advanced diffusion techniques in both brains and spinal cords of patients with MS (neurite orientation dispersion
Fellows’ Journal Club Multiple sclerosis lesions develop around small veins that are radiologically described as the so-called central vein sign. With 7T MR imaging and magnetic susceptibility-based sequences, the central vein sign has been observed in 80%–100% of MS lesions
Editor’s Choice MR imaging–pathologic studies have reported that paramagnetic rims on 7T susceptibility-based MR imaging identify, in vivo, a subset of MS lesions with compartmentalized inflammation at the lesion edge and associated remyelination failure. High-resolution T2* and phase MR imaging
Editor’s Choice The authors compared WM lesions in a group of patients with multiple sclerosis and in a second group of positive controls with white matter lesions who did not have a diagnosis of MS. The presence of a rim
Editor’s Choice Twenty-five patients with relapsing-remitting MS and 20 healthy volunteers were enrolled in a prospective study with a protocol including anatomic imaging, standard magnetization transfer, and inhomogeneous magnetization transfer imaging. Magnetization transfer and inhomogeneous magnetization transfer ratios measured in
Editor’s Choice Fast macromolecular proton fraction mapping is a recent quantitative MR imaging method for myelin assessment. Macromolecular proton fraction and T2* maps were obtained from 12 healthy controls, 18 patients with relapsing-remitting MS, and 12 patients with secondary-progressive MS
